Selected publications
A complete list is available on Google Scholar. * denotes equal contribution.
Connecting human genetic associations to molecular mechanisms
- Functional architecture of rare protein coding variation across 786,871 exomes. Hou K et al. in preparation.
- Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes. Hou K, Pazokitoroudi A, Strober BJ, et al. medRxiv, 2026.
- Temporally distinct 3D multi-omic dynamics in the developing human brain. Heffel MG*, Zhou J*, Zhang Y*, Lee DS*, Hou K*, et al. Nature, 2024.
- Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data. Zhang MJ*, Hou K*, Dey KK, et al. Nature Genetics, 2022.
Defining genetic architecture at biobank scale
- Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture. Hou K*, Burch KS*, Majumdar A, et al. Nature Genetics, 2019.
- On powerful GWAS in admixed populations. Hou K, Bhattacharya A, Mester R, et al. Nature Genetics, 2021.
- Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals. Hou K, Ding Y, Xu Z, et al. Nature Genetics, 2023.
Developing calibrated and individualized disease prediction
- Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification. Ding Y*, Hou K*, Burch KS, et al. Nature Genetics, 2022.
- Polygenic scoring accuracy varies across the genetic ancestry continuum. Ding Y, Hou K, Xu Z, et al. Nature, 2023.
- Calibrated prediction intervals for polygenic scores across diverse contexts. Hou K, Xu Z, Ding Y, et al. Nature Genetics, 2024.